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The autopsy and histologic evaluation of tissues of deceased animals confirmed serotonin syndrome for a causal factor in Demise, with disseminated intravascular coagulopathy and brain edema implicated. Gatch et al. (forty) tested MDAI at one hundred mg/kg, with an identical final result to Palenicek et al. (34): this dose was lethal for all mice. Experiments on thermoregulation clearly showed that MDAI dramatically amplified body temperature accompanied by profound perspiration, particularly when administered to rats housed in groups. This, together with the other findings from this study, suggests a potentially higher risk of serotonergic toxicity once the drug is used by humans in configurations including clubs or rave/dance parties, where ambient temperatures are elevated as a consequence of crowding.
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